The complement system : novel roles in health and disease

The Development of the “One-Hit” or “Single Site” Theory of Complement Mediated Immune Hemolysis....Pages 3-15
The Initiation Complexes of the Classical and Lectin Pathways....Pages 19-43
Complement Genetics....Pages 45-59
Regulation of Complement Receptor Gene Expression....Pages 61-73
Coordination of Adaptive Immune Responses by C3....Pages 77-96
Terminal Complement Complex: Regulation of Formation and Pathophysiological Functions....Pages 97-127
The Many Faces of the Membrane Regulators of Complement....Pages 129-166
New Insights into the Regulation of Complement Activation by Decay Accelerating Factor....Pages 167-185
The Role of Complement in Pregnancy and Fetal Loss....Pages 187-199
Complement Deficiencies: a 2004 Update....Pages 201-228
Microbial Evasion Mechanisms Against Human Complement....Pages 231-248
Complement-Mediated Antibody-Dependent Enhancement of Viral Infections....Pages 249-264
Tumor Cell Resistance to Complement-Mediated Lysis....Pages 265-304
Complement and Autoimmunity....Pages 307-314
The Complex Roles of Anaphylatoxins in Allergic Asthma and Autoimmune Diseases....Pages 315-344
Role of Complement in Allergy....Pages 345-360
Complement Activation-Related Pseudoallergy....Pages 361-396
The Role of Complement in Transplantation....Pages 397-418
Role of Complement in Myocardial Ischemia and Infarction....Pages 421-435
Role of Complement in Intestinal Ischemia/Reperfusion Induced Injury....Pages 437-449
Role of C5a and C5a Receptor in Sepsis....Pages 451-464
Role of Complement in Multi-Organ Dysfunction Syndrome....Pages 465-480
Therapeutic Manipulation of the Complement System....Pages 483-516
Activation and Inhibition of Complement by Immunoglobulins....Pages 517-529
Engineering Control of Complement Inhibition at the Cell Surface....Pages 531-545