Bone Metastasis and Molecular Mechanisms: Pathophysiology

Front Matter....Pages i-xvi
Models of Breast Cancer Metastasis to Bone: Characterization of a Clinically Relevant Model....Pages 1-18
Quantitation of Bone Metastasis in Experimental Systems....Pages 19-30
Comparative Morphometric Study on Bone Remodeling in Human Specimens and in Experimental Models of Metastatic Bone Disease....Pages 31-48
Clinical Modalities for the Diagnosis, Characterization and Detection of Bone Metastases....Pages 49-69
Metastasis in the Bone Marrow Microenvironment....Pages 71-85
The Role of Tumor-Associated Macrophages in Metastasis-Associated Osteolysis....Pages 87-108
The Malignant Hierarchy in Multiple Myeloma: Relationships between Malignant Cells and Bone Disease....Pages 109-138
Angiogenesis and Lymphangiogenesis in Metastatic Bone Disease: A Matter of Networking....Pages 139-162
Prostate Cancer: Models for Developing Novel Therapeutic Approaches....Pages 163-186
Potential Therapeutic Targets for Bone Metastasis....Pages 187-210
OPG, RANK and RANKL in Bone Metastasis and Cancer-Associated Osteolysis....Pages 211-240
Role of Matrix Metalloproteinases in Bone Metastasis from Human Breast and Prostate Cancer....Pages 241-276
The Role of Bisphosphonates in Bone Metastasis....Pages 277-301
Back Matter....Pages 303-308