Integration in Respiratory Control: From Genes to Systems

Front Matter....Pages i-xxxi
History of Measuring O 2 and CO 2 Responses....Pages 3-8
J.S. Haldane and Some of His Contributions to Physiology....Pages 9-15
Control of the Exercise Hyperpnea: The Unanswered Question....Pages 16-21
A Peripheral Oxygen Sensor Provides Direct Activation of an Identified Respiratory CPG Neuron in Lymnaea ....Pages 25-29
Environmental Hyperoxia and Development of Carotid Chemoafferent Function....Pages 30-34
HSP70 Reduces Chronic Hypoxia-Induced Neural Suppression via Regulating Expression of Syntaxin....Pages 35-40
Effect of Systemic Administration of the Nitric Oxide Synthase Inhibitor L-NMMA on the Human Ventilatory Response to Hypoxia....Pages 41-45
Effects of Volatile Anesthetics on Carotid Body Response to Hypoxia in Animals....Pages 46-50
Mutation of the von Hippel-Lindau Gene Alters Human Cardiopulmonary Physiology....Pages 51-56
Intravenous Endothelin-1 and Ventilatory Sensitivity to Hypoxia in Humans....Pages 57-62
Key Roles for AMP-activated Protein Kinase in the Function of the Carotid Body?....Pages 63-68
Stimulatory Actions of Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) in Rat Carotid Glomus Cells....Pages 69-74
Post-hypoxic Unstable Breathing in the C57BL/6J Mouse: Effects of Acetazolamide....Pages 75-79
Catecholaminergic Modulation of the Respiratory Rhythm Generator in the Isolated Brainstem—Spinal Cord Preparation from Neonatal Rat....Pages 83-87
What Role Do Pacemakers Play in the Generation of Respiratory Rhythm?....Pages 88-93
Pre-Bötzinger Complex Neurokinin-1 Receptor Expressing Neurons in Primary Cell Culture....Pages 94-98
Belt-and-Suspenders as a Biological Design Principle....Pages 99-103
Two Modes of Respiratory Rhythm Generation in the Newborn Rat Brainstem-Spinal Cord Preparation....Pages 104-108
Possible Roles of the Weakly Inward Rectifying K + Channel Kir4.1 (KCNJ10) in the Pre-Bötzinger Complex....Pages 109-113
Contribution of Pacemaker Neurons to Respiratory Rhythms Generation in vitro ....Pages 114-118
Emergent Bursting in Small Networks of Model Conditional Pacemakers in the pre-Bötzinger Complex....Pages 119-124
Brain Nuclei Controlling the Spinal Respiratory Motoneurons in the Newborn Mouse....Pages 127-132
Superoxide Dismutase-1 Influences the Timing and Post-hypoxic Stability of Neonatal Breathing....Pages 133-138
Neurodevelopmental Abnormalities in the Brainstem of Prenatal Mice Lacking the Prader-Willi Syndrome Gene Necdin....Pages 139-143
Consequences of Prenatal Exposure to Diazepam on the Respiratory Parameters, Respiratory Network Activity and Gene Expression of α1 and α2 Subunits of GABA A Receptor in Newborn Rat....Pages 144-148
Modulation of Perinatal Respiratory Rhythm by GABA A - and Glycine Receptor-mediated Chloride Conductances....Pages 149-153
Laryngeal Stimulation by an Acid Solution in the Pre-term Lamb....Pages 154-158
Necdin Gene, Respiratory Disturbances and Prader-Willi Syndrome....Pages 159-164
Quantitative Analysis of the Oxygen Transfer in the Human Acinus....Pages 167-172
Role of Diffusion Screening in Pulmonary Diseases....Pages 173-178
A dp/dt Method to Assess Dynamic Properties of Lung Mechanoreceptors....Pages 179-183
Pulmonary Gas Exchange in Anatomically-Based Models of the Lung....Pages 184-189
Multi-scale Models of the Lung Airways and Vascular System....Pages 190-194
Modeling Structure-Function Interdependence of Pulmonary Gas Exchange....Pages 195-200
Ventilatory Control during Intermittent High-Intensity Exercise in Humans....Pages 203-208
Exercise-induced Respiratory Muscle Work: Effects on Blood Flow, Fatigue and Performance....Pages 209-212
Phase Relations Between Rhythmical Movements and Breathing in Wind Instrument Players....Pages 213-217
The Effect of Two Different Intermittent Hypoxia Protocols on Ventilatory Responses to Hypoxia and Carbon Dioxide at Rest....Pages 218-223
Respiratory Long-Term Facilitation: Too Much or Too Little of a Good Thing?....Pages 224-227
Contribution of Endothelin-1 and Endothelin A and B Receptors to the Enhanced Carotid Body Chemosensory Responses Induced by Chronic Intermittent Hypoxia....Pages 228-232
Intermittent Hypoxia Induces Respiratory Long-Term Facilitation in Postnatal Rats....Pages 233-238
Respiratory Control, Respiratory Sensations and Cycling Endurance After Respiratory Muscle Endurance Training....Pages 239-244
Non-dimensional Quantification of the Interactions Between Hypoxia, Hypercapnia and Exercise on Ventilation in Humans....Pages 245-248
Elevated Body Temperature Exaggerates Laryngeal Chemoreflex Apnea in Decerebrate Piglets....Pages 249-254
Effects of Systemic Administration of Mirtazapine on Respiratory Muscle Activity in Sleeping Rats....Pages 257-261
Control of Genioglossus Muscle by Sleep State-Dependent Neuromodulators....Pages 262-267
Significance of Multiple Neurochemicals that Regulate Respiration....Pages 268-273
Disinhibition of the Dorsomedial Hypothalamus Increases the Frequency of Augmented Breaths in the Anesthetized Rat....Pages 274-278
Major Components of Endogenous Neurotransmission Underlying the Discharge Activity of Hypoglossal Motoneurons in vivo ....Pages 279-284
Control of Ventilation in Diving Birds....Pages 287-292
Evolutionary Trends in Respiratory Mechanisms....Pages 293-298
A Computer Model of Mammalian Central CO 2 Chemoreception....Pages 301-305
A Mathematical Model of pH i Regulation in Central CO 2 - Chemoreception....Pages 306-311
Plasticity in the Brain: Influence of Bilateral Carotid Body Resection (bCBR) on Central CO 2 Sensitivity....Pages 312-316
Glial Modulation of CO 2 Chemosensory Excitability in the Retrotrapezoid Nucleus of Rodents....Pages 317-321
The Carotid Chemoreceptors are a Major Determinant of Ventilatory CO 2 Sensitivity and of PaCO 2 During Eupneic Breathing....Pages 322-326
The Retrotrapezoid Nucleus and Central Chemoreception....Pages 327-332
The Chemosensitive Response of Neurons from the Locus Coeruleus (LC) to Hypercapnic Acidosis with Clamped Intracellular pH....Pages 333-337
CO 2 -sensitivity of GABAergic Neurons in the Ventral Medullary Surface of GAD67-GFP Knock-in Neonatal Mice....Pages 338-342
Multiple Central Chemoreceptor Sites: Cell Types and function in vivo ....Pages 343-347
Intrinsic Chemosensitivity of Individual Nucleus Tractus Solitarius (NTS) and Locus Coeruleus (LC) Neurons from Neonatal Rats....Pages 348-352
Chemosensitive Neuronal Network Organization in the Ventral Medulla Analyzed by Dynamic Voltage-Imaging....Pages 353-357
The Effects of a Respiratory Acidosis on Human Heart Rate Variability....Pages 361-365
Neurokinin-1 Receptor Activation in the Bötzinger Complex Evokes Bradypnea and is Involved in Mediating the Hering-Breuer Reflex....Pages 366-370
Brainstem Catecholaminergic Neurons Modulate both Respiratory and Cardiovascular Function....Pages 371-376
Responses of Brainstem Respiratory Neurons to Activation of Midbrain Periaqueductal Gray in the Rat....Pages 377-381
Computational Model of TASK Channels and PKC-Pathway Dependent Serotonergic Modulatory Effects in Respiratory-Related Neurons....Pages 382-386
Modulation of Hering-Breuer Reflex by Ventrolateral Pons....Pages 387-392
Respiratory Network Complexity in Neonatal Rat in vivo and in vitro ....Pages 393-398
Fast Oscillatory Rhythms in Inspiratory Motor Discharge: A Mathematical Model....Pages 401-406
Burst-to-Burst Variability in Respiratory Timing, Inspiratory-Phase Spectral Activity, and Inspiratory Neural Network Complexity in Urethane-Anesthetized C57BL/6 Mice in vivo ....Pages 407-412
Effects of Hypercapnia on Non-nutritive Swallowing in Newborn Lambs....Pages 413-417
CPAP Inhibits Non-nutritive Swallowing Through Stimulation of Bronchopulmonary Receptors....Pages 418-422
Glutamatergic Neurotransmission is Not Essential for, but Plays a Modulatory Role in, the Production of Gasping in Arterially-Perfused Adult Rat....Pages 423-427
Potential Mechanism for Transition Between Acute Hypercapnia During Sleep to Chronic Hypercapnia During Wakefulness in Obstructive Sleep Apnea....Pages 431-436
Biochemical Control of Airway Motor Neurons During Rapid Eye Movement Sleep....Pages 437-441
Prediction of Periodic Breathing at Altitude....Pages 442-446
A Negative Interaction Between Central and Peripheral Respiratory Chemoreceptors May Underlie Sleep-Induced Respiratory Instability: A Novel Hypothesis....Pages 447-451
Ventilatory Response to Hypercapnia in Pre-menopausal and Post-menopausal Women....Pages 452-457
Oxidative Stress Impairs Upper Airway Muscle Endurance in an Animal Model of Sleep-Disordered Breathing....Pages 458-462
Ventilatory and Blood Pressure Responses to Isocapnic Hypoxia in OSA Patients....Pages 463-468
Modeling of Sleep-Induced Changes in Airway Function: Implication for Nocturnal Worsening of Bronchial Asthma....Pages 469-474
The Effects of Wakefulness State on the Temporal Characteristics of Ventilatory Variables in Man....Pages 475-479
Cerebral Blood Flow and Ventilatory Sensitivity to CO 2 Measured with the Modified Rebreathing Method....Pages 480-485
Naloxone Reversal of Opioid-Induced Respiratory Depression with Special Emphasis on the Partial Agonist/Antagonist Buprenorphine....Pages 486-491
The Pulse Oxygen Saturation: Inspired Oxygen Pressure (SpO 2 :P 1 O 2 ) Diagram: Application in the Ambulatory Assessment of Pulmonary Vascular Disease....Pages 492-496
Hypocapnia and Airway Resistance in Normal Humans....Pages 497-502
Disturbances of Breathing in Rett Syndrome: Results from Patients and Animal Models....Pages 503-507
NHE3 in the Human Brainstem: Implication for the Pathogenesis of the Sudden Infant Death Syndrome (SIDS)?....Pages 508-513
The Ventilatory Response to Exercise Does Not Differ Between Obese Women With and Without Dyspnea on Exertion....Pages 514-518
Back Matter....Pages 519-541