Function and Regulation of Cellular Systems

Front Matter....Pages i-x
Front Matter....Pages 1-1
Introduction to Part I....Pages 3-5
A Functional Dynamics Approach to Modelling of Glycolysis....Pages 7-18
Temperature-Compensation in Biological Clocks: Models and Experiments....Pages 19-29
Metabolic Control Analysis of the ATPase Network in Contracting Muscle: Regulation of Contractile Function and ATP Free Energy Potential....Pages 31-46
En Route for Systems Biology: In Silico Pathway Analysis and Metabolite Profiling....Pages 47-58
Front Matter....Pages 59-59
Introduction to Part II....Pages 61-62
Presynaptic Calcium Dynamics of Neurons in Answer to Various Stimulation Protocols....Pages 63-71
Mathematical Modeling of Signaling Cascades: Principles and Future Prospects....Pages 73-87
Collective Behavior of Membrane Channels:Electro-Physiological Studies on Gap Junctions....Pages 89-97
Modelling of Periodic Intercellular Ca 2+ Waves....Pages 99-110
Travelling Waves as a Mechanism of Pattern Generation in Discrete Cell Lattices....Pages 111-118
Design and Operation: Keys to Understanding Biological Systems....Pages 119-131
Front Matter....Pages 133-133
Introduction to Part III....Pages 135-137
Biopolymer Dynamics....Pages 139-150
Micromechanics of Molecular Motors: Experiments and Theory....Pages 151-176
The Role of Osteocalcin in the Remodeling of Biomimetic Hydroxyapatite-Collagen Materials for Bone Replacement....Pages 177-183
Cell Shape Normalization of Normal and Haploinsufficient NF1-Melanocytes by Micro-Structured Substrate Interaction....Pages 185-197
Quantification of Shear Stress-Induced Cell Migration in Endothelial Cultures....Pages 199-207
Front Matter....Pages 209-209
Introduction to Part IV....Pages 211-212
Constructive and Dynamical Systems Approach to Life....Pages 213-224
Front Matter....Pages 209-209
Coherent Dynamics in Networks of Single Protein Molecules....Pages 225-232
Gene Regulatory Networks: A Discrete Model of Dynamics and Topological Evolution....Pages 233-239
Evolutionary Reconstruction of Networks....Pages 241-249
Modelling Simple Biochemical Networks....Pages 251-257
On the Evolution of Information in the Constituents of Regulatory Gene Networks....Pages 259-264
Front Matter....Pages 265-265
Introduction to Part V....Pages 267-268
Biological Relevance of Tissue Liquidity and Viscoelasticity....Pages 269-277
Reinforcement of Cytoskeleton-Matrix Bonds and Tensiotaxis: A Cell-Based Model....Pages 279-286
Simulation of Haematopoietic Stem Cell Organisation Using a Single Cell Based Model Approach....Pages 287-293
Pattern Formation in an Interacting Cell System: Rippling in Myxobacterial Aggregates....Pages 295-301
Front Matter....Pages 303-303
Introduction to Part VI....Pages 305-308
Molecular and Cellular Analysis of De Novo Pattern Formation in Hydra ....Pages 309-321
The Small Freshwater Polyp Hydra as a Model for Axis Formation in Higher Organisms....Pages 323-333
Cell Migration, Cell Fate and Pattern Formation During Head Development in Lungfishes and Amphibians....Pages 335-346
Cell-Based Modelling of Tissues....Pages 347-359
Front Matter....Pages 361-361
Introduction to Part VII....Pages 363-365
Cell-Based Models of Avascular Tumor Growth....Pages 367-378
Solid Tumour Invasion:The Importance of Cell Adhesion....Pages 379-389
Interrelationship of Tumour and Immune System....Pages 391-398
Nonlinear Dynamics and Statistical Physics of Models for the Immune System....Pages 399-410
Front Matter....Pages 361-361
Stochastic Model of Influenza Virus Fusion....Pages 411-420
Spatio-Temporal Aspects of a Dynamical Disease: Waves of Spreading Depression....Pages 421-434
Back Matter....Pages 435-450